Sunita (Jiah Khan) is a medical student and is working on a project about the human brain with her classmates. When she was denied access by her professor to the curious case of Sanjay Singhania (Aamir Khan), a man reported to have anterograde amnesia, because it is under criminal investigation, Sunita decides to investigate the matter herself.
It is later revealed that Sanjay loses his memory every 15 minutes. He uses a system of photographs, notes, and tattoos on his body to recover his memory after each cycle to remind himself of his mission: to avenge the death of his wife Kalpana (Asin). He systematically kills the people who were involved to the murder. His main target is Ghajini Dharmatma (Pradeep Rawat), a notable social personality in the city, and the man directly responsible for Kalpana's death and Sanjay's condition.
It is later revealed that Sanjay loses his memory every 15 minutes. He uses a system of photographs, notes, and tattoos on his body to recover his memory after each cycle to remind himself of his mission: to avenge the death of his wife Kalpana (Asin). He systematically kills the people who were involved to the murder. His main target is Ghajini Dharmatma (Pradeep Rawat), a notable social personality in the city, and the man directly responsible for Kalpana's death and Sanjay's condition.
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